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KMID : 0191119980130060612
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Journal of Korean Medical Science
1998 Volume.13 No. 6 p.612 ~ p.616
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Combination chemotherapy of oral 5´-deoxy-5-fluorouridine and cisplatin in advanced gastric cancer: a phase II study
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Ahn MJ
Han DS/Sohn JH/Jeon YC/Jun DW/Choi NW/Park HK/Baik HK/Lee HG/Nam YS/Choi IY
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Abstract
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This study was designed to test the activity and feasibility of 5'-deoxy-5-fluorouridine (5'-DFUR) and cisplatin combination therapy in the treatment of advanced gastric cancer. Nineteen patients with inoperable and/or metastatic gastric cancer, which was histologically proven, were orally administered 5'-DFUR 1,200 mg/m2 on days 1 to 4 and days 15-18 combined with 70 mg/m2 of cisplatin being repeated every 4 weeks. Five partial responses (PRs) were achieved. Seven patients had stable disease and 6 progressed on therapy. The overall response rate was 27.7% (95% confidence interval: 9.69% to 53.5%). The median survival duration of all 18 patients was 25 weeks (9-64). The majority of patients had WHO grade I/II toxicity, but there was no treatment-related death. These data support that the combinations of oral 5'-DFUR and cisplatin are well tolerable and have a moderate activity with low toxicity in the treatment of advanced gastric cancer.
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KEYWORD
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